「view this page in B3 βῆτα server」

Revisions №61341

branch: master 「№61341」
Commited by: Vikram K. Mulligan
GitHub commit link: 「886e40432568875a」 「№4769」
Difference from previous tested commit:  code diff
Commit date: 2020-07-15 18:55:38

Merge pull request #4769 from RosettaCommons/vmullig/peptide_pnear_vs_ic_scitest Add a scientific test for the correlation between peptide computed PNear and experimentally-measured IC50. The rigidity of a peptide macrocycle is a determinant of binding affinity. When peptides are optimized for favourable interactions with a target, computed PNear (or DeltaG_folding) values correlate well with experimentally-measured IC50 values. This correlation has improved as the Rosetta energy function has improved, from a vague correlation with talaris2013 and talaris2014 to a pretty good correlation that actually predicts rank order with ref2015. (This is likely due to the practice of training against physics-based fluid simulations used for ref2015.) It would be good to ensure that this trend continues for future versions of the energy function, so I'm adding a scientific test.

...